Ke Hou, Peng Ge, Michael R. Sawaya, Joshua L. Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David R. Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigon, David S. Eisenberg, How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer’s disease brain by a strain-relief mechanism
bioRxiv doi: 10.1101/2024.03.25.586668
2024
Ke Hou, Hope Pan, Hedieh Shahpasand-Kroner, Carolyn Hu, Romany Abskharon, Seidler, Marisa Mekkittiku, Melinda Balbirnie, Carter Lantz,
Michael R. Sawaya, Joshua L. Dolinsky, Mychica Jones, Xiaohong Zuo, Joseph A. Loo, Sally Frautschy, Greg Cole, David S. Eisenberg
D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer’s disease
Sci Adv. 2024 May 3;10(18):eadl2991. 2024 PMID: 38691615
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Nguyen BA, Singh V, Afrin S, Yakubovska A, Wang L, Ahmed Y, Pedretti R, Fernandez-Ramirez MDC, Singh P, Pekala M, Cabrera Hernandez LO, Kumar S, Lemoff A, Gonzalez-Prieto R, Sawaya MR, Eisenberg DS, Benson MD, Saelices L
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy
Nat Commun. 2024 Jan 17;15(1):581 2024 PMID: 38233397
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2023
Abskharon, R, Pan H, Sawaya MR, Seidler PM, Olivares, EJ, Chen Y, Murray KA, Zhang J, Lantz C, Bentzel M, Boyer DR, Cascio D, Nguyen BA, Hou K, Cheng X, Parton E, Williams CK, Nana AL, Vinters HV, Spina S, Grinberg LT, Seeley WW, Steyaert J, Glabe CG, Loo RO, Loo JA, Eisenberg D
Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils
PNAS. October 2023. 120:41, e2300258120; 2023 PMID: 37801475
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Kevin A. Murray, Carolyn J. Hu, Hope Pan, Jiahui Lu, Romany Abskharon, Jeannette T. Bowler, Gregory M. Rosenberg, Christopher K. Williams, Gazmend Elezi, Melinda Balbirnie, Kym F. Faull, Harry V. Vinters, Paul M. Seidler, and David S. Eisenberg
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils
Proc Natl Acad Sci USA . 2023 Feb 14;120(7):e2217835120. doi: 10.1073/pnas.2217835120. Epub 2023 Feb 9. 2023 PMID: 36757890
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2022
Seidler PM, Murray KA, Boyer DR, Ge P, Sawaya MR, Hu CJ, Cheng X, Abskharon R, Pan H, DeTure MA, Williams CK, Dickson DW, Vinters HV, Eisenberg DS.
Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro
Nat Commun. 2022 Sep 16;13(1):5451. 2022 PMID: 36114178
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Amaruka Hazari, Michael Sawaya, Niko Vlahakis, Timothy C Johnstone, David Boyer, Jose Rodriguez, David Eisenberg and Jevgenij A. Raskatov
The rippled β-sheet layer configuration—a novel supramolecular architecture based on predictions by Pauling and Corey
J. Am. Chem. Soc. 2023, 145, 47, 25917-25926 Publication Date:November 16, 2023 2022
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Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, Dickson DW, Fu JY, Ogorzalek Loo RR, Loo JA, Eisenberg DS.
Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43
Nature. 2022 Mar 28 2022 PMID: 35344984
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2021
Shipps C, Kelly HR, Dahl PJ, Yi SM, Vu D, Boyer D, Glynn C, Sawaya MR, Eisenberg D, Batista VS, Malvankar NS
Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines.
Proc Natl Acad Sci U S A. 01 2021. 118(2):. 2021 PMID: 33372136
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Tayeb-Fligelman E, Cheng X, Tai C, Bowler JT, Griner S, Sawaya MR, Seidler PM, Jiang YX, Lu J, Rosenberg GM, Salwinski L, Abskharon R, Zee CT, Hou K, Li Y, Boyer DR, Murray KA, Falcon G, Anderson DH, Cascio D, Saelices L, Damoiseaux R, Guo F, Eisenberg DS
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2.
bioRxiv. Mar 2021. :. 2021 PMID: 33688654
|
Shipps C, Kelly HR, Dahl PJ, Yi SM, Vu D, Boyer D, Glynn C, Sawaya MR, Eisenberg D, Batista VS, Malvankar NS
Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines.
Proc Natl Acad Sci U S A. Jan 2021. 118(2):. 2021 PMID: 33372136
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2020
Ke PC, Zhou R, Serpell LC, Riek R, Knowles TPJ, Lashuel HA, Gazit E, Hamley IW, Davis TP, Fändrich M, Otzen DE, Chapman MR, Dobson CM, Eisenberg DS, Mezzenga R
Half a century of amyloids: past, present and future.
Chem Soc Rev. Jul 2020. :. 2020 PMID: 32632432
|
Abskharon R, Seidler PM, Sawaya MR, Cascio D, Yang TP, Philipp S, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Felgner PL, Nakajima R, Glabe CG, Eisenberg DS
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer
J. Biol. Chem.. Jun 2020. :. 2020 PMID: 32493775
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Glynn C, Sawaya MR, Ge P, Gallagher-Jones M, Short CW, Bowman R, Apostol M, Zhou ZH, Eisenberg DS, Rodriguez JA
Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core.
Nat. Struct. Mol. Biol.. Apr 2020. :. 2020 PMID: 32284600
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2019
Basavalingappa V, Bera S, Xue B, Azuri I, Tang Y, Tao K, Shimon LJW, Sawaya MR, Kolusheva S, Eisenberg DS, Kronik L, Cao Y, Wei G, Gazit E
Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid.
Nat Commun. Nov 2019. 10(1):5256. 2019 PMID: 31748568
|
Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS
Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau.
Elife. Oct 2019. 8:. 2019 PMID: 31612856
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Seidler PM, Boyer DR, Murray KA, Yang TP, Bentzel M, Sawaya MR, Rosenberg G, Cascio D, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Eisenberg DS
Structure-based inhibitors halt prion-like seeding by Alzheimer's disease- and tauopathy-derived brain tissue samples
J. Biol. Chem.. Sep 2019. :. 2019 PMID: 31537646
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Lu J, Cao Q, Wang C, Zheng J, Luo F, Xie J, Li Y, Ma X, He L, Eisenberg D, Nowick J, Jiang L, Li D
Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation.
Front Mol Neurosci. 2019. 12:54. 2019 PMID: 30886570
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2018
Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L
Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.
Nat Chem. Dec 2018. 10(12):1267. 2018 PMID: 30420778
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Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA
Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.
Nat. Struct. Mol. Biol.. Jan 2018. :. 2018 PMID: 29335561
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Vogler TO, Wheeler JR, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, Johnson AM, Olwin BB, Parker R
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.
Nature. 11 2018. 563(7732):508-513. 2018 PMID: 30464263
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Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L
Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel.
Nat Commun. 09 2018. 9(1):3609. 2018 PMID: 30190461
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Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L
Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.
Nat Chem. Dec 2018. 10(12):1213-1221. 2018 PMID: 30297750
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2017
Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS
Common fibrillar spines of amyloid-β and human Islet Amyloid Polypeptide revealed by Micro Electron Diffraction and inhibitors developed using structure-based design.
J. Biol. Chem.. Dec 2017. :. 2017 PMID: 29282295
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Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS
Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).
Proc. Natl. Acad. Sci. U.S.A.. Jul 2017. :. 2017 PMID: 28760994
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Popp D, Loh ND, Zorgati H, Ghoshdastider U, Liow LT, Ivanova MI, Larsson M, DePonte DP, Bean R, Beyerlein KR, Gati C, Oberthuer D, Arnlund D, Brändén G, Berntsen P, Cascio D, Chavas LMG, Chen JPJ, Ding K, Fleckenstein H, Gumprecht L, Harimoorthy R, Mossou E, Sawaya MR, Brewster AS, Hattne J, Sauter NK, Seibert M, Seuring C, Stellato F, Tilp T, Eisenberg DS, Messerschmidt M, Williams GJ, Koglin JE, Makowski L, Millane RP, Forsyth T, Boutet S, White TA, Barty A, Chapman H, Chen SL, Liang M, Neutze R, Robinson RC
Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser.
Cytoskeleton (Hoboken). Jun 2017. :. 2017 PMID: 28574190
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de la Cruz, M. Jason; Hattne, Johan; Shi, Dan; Seidler, Paul; Rodriguez, Jose; Reyes, Francis; Sawaya, Michael R.; Cascio, Duilio; Weiss, Simon C.; Kim, Sun Kyung; Hinck, Cynthia S.; Hinck, Andrew P.; Calero, Guillermo; Eisenberg, David; Gonen, Tamir
Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED
Nature Methods, DOI:10.1038/NMETH.4178 2017
|
Pascal Krotee, Jose A Rodriguez, Michael R Sawaya, Duilio Cascio, Francis E Reyes, Dan Shi, Johan Hattne, Brent L Nannenga, Marie E Oskarsson, Stephan Philipp, Sarah Griner, Lin Jiang, Charles G Glabe, Gunilla T Westermark, Tamir Gonen, David S Eisenberg
Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity
Elife. 2017 Jan 3;6. pii: e19273. doi: 10.7554/eLife.19273 2017 PMID: 28045370
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2016
Thanh D. Do, Nichole E. LaPointe, Rebecca Nelson, Pascal Krotee, Eric Y. Hayden, Brittany Ulrich, Sarah Quan, Stuart C. Feinstein, David B. Teplow, David Eisenberg, Joan-Emma Shea, and Michael T. Bowers
Amyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels
J. Am. Chem. Soc., 2016, 138 (2), pp 549–557 DOI: 10.1021/jacs.5b09536 2016
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Colletier JP, Sawaya MR, Gingery M, Rodriguez JA, Cascio D, Brewster AS, Michels-Clark T, Hice RH, Coquelle N, Boutet S, Williams GJ, Messerschmidt M, DePonte DP, Sierra RG, Laksmono H, Koglin JE, Hunter MS, Park HW, Uervirojnangkoorn M, Bideshi DK, Brunger AT, Federici BA, Sauter NK, Eisenberg DS
De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure.
Nature. Sep 2016. :. 2016 PMID: 27680699
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Soragni A, Janzen DM, Johnson LM, Lindgren AG, Thai-Quynh Nguyen A, Tiourin E, Soriaga AB, Lu J, Jiang L, Faull KF, Pellegrini M, Memarzadeh S, Eisenberg DS
A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas.
Cancer Cell. Jan 2016. 29(1):90-103. 2016 PMID: 26748848
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2015
Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS
Structure of the toxic core of α-synuclein from invisible crystals.
Nature. Sep 2015. :. 2015 PMID: 26352473
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Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, Riekel C, Colletier JP, Riek R, Eisenberg DS, Simon HU
Toxicity of Eosinophil MBP Is Repressed by Intracellular Crystallization and Promoted by Extracellular Aggregation.
Mol. Cell. Feb 2015. :. 2015 PMID: 25728769
|
Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ
Human prion protein sequence elements impede cross-species chronic wasting disease transmission.
J. Clin. Invest.. Feb 2015. :. 2015 PMID: 25705888
|
2014
Li D, Jones EM, Sawaya MR, Furukawa H, Luo F, Ivanova M, Sievers SA, Wang W, Yaghi OM, Liu C, Eisenberg DS
Structure-based design of functional amyloid materials.
J. Am. Chem. Soc.. Dec 2014. 136(52):18044-51. 2014 PMID: 25474758
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Sawaya MR, Cascio D, Gingery M, Rodriguez J, Goldschmidt L, Colletier JP, Messerschmidt MM, Boutet S, Koglin JE, Williams GJ, Brewster AS, Nass K, Hattne J, Botha S, Doak RB, Shoeman RL, DePonte DP, Park HW, Federici BA, Sauter NK, Schlichting I, Eisenberg DS
Protein crystal structure obtained at 2.9 Å resolution from injecting bacterial cells into an X-ray free-electron laser beam.
Proc. Natl. Acad. Sci. U.S.A.. Sep 2014. 111(35):12769-74. 2014 PMID: 25136092
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Hochberg GK, Ecroyd H, Liu C, Cox D, Cascio D, Sawaya MR, Collier MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JL, Laganowsky A
The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity.
Proc. Natl. Acad. Sci. U.S.A.. Apr 2014. 111(16):E1562-70. 2014 PMID: 24711386
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2013
Miallau L, Jain P, Arbing MA, Cascio D, Phan T, Ahn CJ, Chan S, Chernishof I, Maxson M, Chiang J, Jacobs WR, Eisenberg DS
Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes.
Structure. Apr 2013. 21(4):627-37. 2013 PMID: 23523424
|
Arbing MA, Chan S, Harris L, Kuo E, Zhou TT, Ahn CJ, Nguyen L, He Q, Lu J, Menchavez PT, Shin A, Holton T, Sawaya MR, Cascio D, Eisenberg D
Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions.
PLoS ONE. 2013. 8(11):e81753. 2013 PMID: 24312350
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2012
Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D
Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates
Proc. Natl. Acad. Sci. U.S.A.. Dec 2012. 109(51):20913-8. 2012 PMID: 23213214
|
Gallat FX, Laganowsky A, Wood K, Gabel F, van Eijck L, Wuttke J, Moulin M, Härtlein M, Eisenberg D, Colletier JP, Zaccai G, Weik M
Dynamical coupling of intrinsically disordered proteins and their hydration water: comparison with folded soluble and membrane proteins.
Biophys. J.. Jul 2012. 103(1):129-36. 2012 PMID: 22828339
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Kato M, Han TW, Xie S, Shi K, Du X, Wu LC, Mirzaei H, Goldsmith EJ, Longgood J, Pei J, Grishin NV, Frantz DE, Schneider JW, Chen S, Li L, Sawaya MR, Eisenberg D, Tycko R, McKnight SL
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels.
Cell. May 2012. 149(4):753-67. 2012 PMID: 22579281
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Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D
Atomic view of a toxic amyloid small oligomer.
Science. Mar 2012. 335(6073):1228-31. 2012 PMID: 22403391
|
2011
Aranda B, Blankenburg H, Kerrien S, Brinkman FS, Ceol A, Chautard E, Dana JM, De Las Rivas J, Dumousseau M, Galeota E, Gaulton A, Goll J, Hancock RE, Isserlin R, Jimenez RC, Kerssemakers J, Khadake J, Lynn DJ, Michaut M, O'Kelly G, Ono K, Orchard S, Prieto C, Razick S, Rigina O, Salwinski L, Simonovic M, Velankar S, Winter A, Wu G, Bader GD, Cesareni G, Donaldson IM, Eisenberg D, Kleywegt GJ, Overington J, Ricard-Blum S, Tyers M, Albrecht M, Hermjakob H
PSICQUIC and PSISCORE: accessing and scoring molecular interactions.
Nat. Methods. Jul 2011. 8(7):528-9. 2011 PMID: 21716279
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Chim N, Habel JE, Johnston JM, Krieger I, Miallau L, Sankaranarayanan R, Morse RP, Bruning J, Swanson S, Kim H, Kim CY, Li H, Bulloch EM, Payne RJ, Manos-Turvey A, Hung LW, Baker EN, Lott JS, James MN, Terwilliger TC, Eisenberg DS, Sacchettini JC, Goulding CW
The TB Structural Genomics Consortium: a decade of progress.
Tuberculosis (Edinb). Mar 2011. 91(2):155-72. 2011 PMID: 21247804
|
2009
Salwinski L, Licata L, Winter A, Thorneycroft D, Khadake J, Ceol A, Aryamontri AC, Oughtred R, Livstone M, Boucher L, Botstein D, Dolinski K, Berardini T, Huala E, Tyers M, Eisenberg D, Cesareni G, Hermjakob H
Recurated protein interaction datasets.
Nat. Methods. Dec 2009. 6(12):860-1. 2009 PMID: 19935838
|
Maji SK, Perrin MH, Sawaya MR, Jessberger S, Vadodaria K, Rissman RA, Singru PS, Nilsson KP, Simon R, Schubert D, Eisenberg D, Rivier J, Sawchenko P, Vale W, Riek R
Functional amyloids as natural storage of peptide hormones in pituitary secretory granules.
Science. Jul 2009. 325(5938):328-32. 2009 PMID: 19541956
|
2008
Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL
Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy.
J. Clin. Invest.. Aug 2008. 118(8):2917-28. 2008 PMID: 18636118
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2007
Orchard S, Salwinski L, Kerrien S, Montecchi-Palazzi L, Oesterheld M, Stümpflen V, Ceol A, Chatr-aryamontri A, Armstrong J, Woollard P, Salama JJ, Moore S, Wojcik J, Bader GD, Vidal M, Cusick ME, Gerstein M, Gavin AC, Superti-Furga G, Greenblatt J, Bader J, Uetz P, Tyers M, Legrain P, Fields S, Mulder N, Gilson M, Niepmann M, Burgoon L, De Las Rivas J, Prieto C, Perreau VM, Hogue C, Mewes HW, Apweiler R, Xenarios I, Eisenberg D, Cesareni G, Hermjakob H
The minimum information required for reporting a molecular interaction experiment (MIMIx).
Nat. Biotechnol.. Aug 2007. 25(8):894-8. 2007 PMID: 17687370
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Murillo AC, Li HY, Alber T, Baker EN, Berger JM, Cherney LT, Cherney MM, Cho YS, Eisenberg D, Garen CR, Goulding CW, Hung LW, Ioerger TR, Jacobs WR, James MN, Kim C, Krieger I, Lott JS, Sankaranarayanan R, Segelke BW, Terwilliger TC, Wang F, Wang S, Sacchettini JC
High throughput crystallography of TB drug targets.
Infect Disord Drug Targets. Jun 2007. 7(2):127-39. 2007 PMID: 17970224
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Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AØ, Riekel C, Eisenberg D
Atomic structures of amyloid cross-beta spines reveal varied steric zippers.
Nature. May 2007. 447(7143):453-7. 2007 PMID: 17468747
|
Yooseph S, Sutton G, Rusch DB, Halpern AL, Williamson SJ, Remington K, Eisen JA, Heidelberg KB, Manning G, Li W, Jaroszewski L, Cieplak P, Miller CS, Li H, Mashiyama ST, Joachimiak MP, van Belle C, Chandonia JM, Soergel DA, Zhai Y, Natarajan K, Lee S, Raphael BJ, Bafna V, Friedman R, Brenner SE, Godzik A, Eisenberg D, Dixon JE, Taylor SS, Strausberg RL, Frazier M, Venter JC
The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families.
PLoS Biol.. Mar 2007. 5(3):e16. 2007 PMID: 17355171
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White EL, Southworth K, Ross L, Cooley S, Gill RB, Sosa MI, Manouvakhova A, Rasmussen L, Goulding C, Eisenberg D, Fletcher TM
A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase.
J Biomol Screen. Feb 2007. 12(1):100-5. 2007 PMID: 17175524
|
Kerrien S, Orchard S, Montecchi-Palazzi L, Aranda B, Quinn AF, Vinod N, Bader GD, Xenarios I, Wojcik J, Sherman D, Tyers M, Salama JJ, Moore S, Ceol A, Chatr-Aryamontri A, Oesterheld M, Stumpflen V, Salwinski L, Nerothin J, Cerami E, Cusick ME, Vidal M, Gilson M, Armstrong J, Woollard P, Hogue C, Eisenberg D, Cesareni G, Apweiler R, Hermjakob H
Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions.
BMC Biol.. 2007. 5:44. 2007 PMID: 17925023
|
2006
Abdallah AM, Verboom T, Hannes F, Safi M, Strong M, Eisenberg D, Musters RJ, Vandenbroucke-Grauls CM, Appelmelk BJ, Luirink J, Bitter W
A specific secretion system mediates PPE41 transport in pathogenic mycobacteria.
Mol. Microbiol.. Nov 2006. 62(3):667-79. 2006 PMID: 17076665
|
Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.
Science. Mar 2006. 311(5768):1770-3. 2006 PMID: 16497887
|
2004
Hermjakob H, Montecchi-Palazzi L, Bader G, Wojcik J, Salwinski L, Ceol A, Moore S, Orchard S, Sarkans U, von Mering C, Roechert B, Poux S, Jung E, Mersch H, Kersey P, Lappe M, Li Y, Zeng R, Rana D, Nikolski M, Husi H, Brun C, Shanker K, Grant SG, Sander C, Bork P, Zhu W, Pandey A, Brazma A, Jacq B, Vidal M, Sherman D, Legrain P, Cesareni G, Xenarios I, Eisenberg D, Steipe B, Hogue C, Apweiler R
The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data.
Nat. Biotechnol.. Feb 2004. 22(2):177-83. 2004 PMID: 14755292
|
Pellegrini M, Fitz-Gibbon ST, Yeates T, Eisenberg D
Phylogenetic Profiling
Wiley Publishers, The Atrium, (2004). 2004
|
2003
Hsu T, Hingley-Wilson SM, Chen B, Chen M, Dai AZ, Morin PM, Marks CB, Padiyar J, Goulding C, Gingery M, Eisenberg D, Russell RG, Derrick SC, Collins FM, Morris SL, King CH, Jacobs WR
The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue.
Proc. Natl. Acad. Sci. U.S.A.. Oct 2003. 100(21):12420-5. 2003 PMID: 14557547
|
Goulding CW, Perry LJ, Anderson D, Sawaya MR, Cascio D, Apostol MI, Chan S, Parseghian A, Wang SS, Wu Y, Cassano V, Gill HS, Eisenberg D
Structural genomics of Mycobacterium tuberculosis: a preliminary report of progress at UCLA.
Biophys. Chem.. Sep 2003. 105(2-3):361-70. 2003 PMID: 14499904
|
Terwilliger TC, Park MS, Waldo GS, Berendzen J, Hung LW, Kim CY, Smith CV, Sacchettini JC, Bellinzoni M, Bossi R, De Rossi E, Mattevi A, Milano A, Riccardi G, Rizzi M, Roberts MM, Coker AR, Fossati G, Mascagni P, Coates AR, Wood SP, Goulding CW, Apostol MI, Anderson DH, Gill HS, Eisenberg DS, Taneja B, Mande S, Pohl E, Lamzin V, Tucker P, Wilmanns M, Colovos C, Meyer-Klaucke W, Munro AW, McLean KJ, Marshall KR, Leys D, Yang JK, Yoon HJ, Lee BI, Lee MG, Kwak JE, Han BW, Lee JY, Baek SH, Suh SW, Komen MM, Arcus VL, Baker EN, Lott JS, Jacobs W, Alber T, Rupp B
The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.
Tuberculosis (Edinb). 2003. 83(4):223-49. 2003 PMID: 12906835
|
Cech TR, Eddy SR, Eisenberg D, Hersey K, Holtzman SH, Poste GH, Raikhel NV, Scheller RH, Singer DB, Waltham MC
Sharing publication-related data and materials: responsibilities of authorship in the life sciences
National Academics Committee on Responsibilities of Authorship in the Biological Sciences. Plant Physiology, 132(1):19-24, (2003). 2003
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2002
Goulding CW, Apostol M, Anderson DH, Gill HS, Smith CV, Kuo MR, Yang JK, Waldo GS, Suh SW, Chauhan R, Kale A, Bachhawat N, Mande SC, Johnston JM, Lott JS, Baker EN, Arcus VL, Leys D, McLean KJ, Munro AW, Berendzen J, Sharma V, Park MS, Eisenberg D, Sacchettini J, Alber T, Rupp B, Jacobs W, Terwilliger TC
The TB structural genomics consortium: providing a structural foundation for drug discovery.
Curr Drug Targets Infect Disord. Jun 2002. 2(2):121-41. 2002 PMID: 12462144
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Goulding CW, Apostol M, Anderson DH, Gill HS, Smith CV, Kuo MR, Yang JK, Waldo GS, Suh SW, Chauhan R, Kale A, Bachhawat N, Mande SC, Johnston JM, Lott JS, Baker EN, Arcus VL, Leys D, McLean KJ, Munro AW, Berendzen J, Sharma V, Park MS, Eisenberg D, Sacchettini J, Alber T, Rupp B, Jacobs W Jr, Terwilliger TC.
The TB Structural Genomics Consortium: Providing a Structural Foundation for Drug Discovery
Current Drug Targets – Infectious Disorders, 2, 121-141, (2002). 2002
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2001
Dym O, Eisenberg D, Yeates TO
Chapter 21.3 Detection of Errors in Protein Models
in International Tables for Crystallography, Volume F. Crystallography of Biological Macromolecules, ed. M.G. Rossmann and E. Arnold. Dordrecht: Kluwer Academic Publishers, The Netherlands, pp. 520-525 (2001). 2001
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1997
Eisenberg D
Structural Biology and the Human Genome
In Industry-University Partnerships in Research: Proceedings of the Third Annual Seaborg Symposium, UCLA, October 12, 1996. Ed. B.A. Levey, pp. 29-34, Regents of the University of California, Los Angeles (1997). 1997
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1996
Ogihara NL, Parge HE, Hart PJ, Weiss MS, Goto JJ, Crane BR, Tsang J, Slater K, Roe JA, Valentine JS, Eisenberg D, Tainer JA
Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase.
Biochemistry. Feb 1996. 35(7):2316-21. 1996 PMID: 8652572
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Weiss, M., Bell, C.E., Bennett, M.J., Collier, R.J., Schlunegger, M.P., Steere, B.A., and Eisenberg, D.
A Structure-Based Model of Diphtheria Toxin Action
In Protein Toxin Structure, M. Parker, Ed. R.G. Landes Company, Texas, pp. 25-47 (1996). 1996
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Stowell, M.H.B., Soltis, S.M., Kisker, C., Peter, J.W., Schindelin, H., Rees, D.C., Cascio, D., Beamer, L., Hart, P.J., Eisenberg, D., Wiener, M.C. and Whitby, F.G.
A Simple Device for Studying Macromolecular Crystals Under Moderate Gas Pressures (0.1 - 10 MPa)
J. Appl. Cryst., 29, 608 (1996). 1996
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1991
Luthy R, Eisenberg D
Protein
in Sequence Analysis Primer, eds. M. Gribskov and J. Devereux, pp. 61-87, Stockton Press, New York (1991). 1991
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1990
Schreuder HA, Curmi PMG, Cascio D, Eisenberg D
The RuBisCO Saga
in Accuracy and Reliability of Macromolecular Crystal Structures, eds. K. Hendrick, D.S. Moss, and I. J. Tickle. Proceedings of a Symposium. Science and Engineering Research Council, Daresbury Lab (1990). 1990
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1987
Eisenberg D, Almassy RJ, Janson CA, Chapman MS, Suh SW, Cascio D, Smith WW
Some evolutionary relationships of the primary biological catalysts glutamine synthetase and RuBisCO.
In Cold Spring Harbor Symposia on Quantitative Biology, Vol. LII, ed. Barker, P. and Brown, D., pp. 483--490, Cold Spring Harbor Laboratory, New York (1987). 1987 PMID: 2900091
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Baldwin RL, Eisenberg D
Protein Stability
UCLA Symposium, in Protein Engineering, ed. by D. Oxender, pp. 127-148, Alan R. Liss, New York (1987). 1987
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Kantardjieff KA, Dijkstra BW, Westbrook EM, Barbieri JT, Carroll SF, Collier RJ, Eisenberg D
Structural Studies of Diphtheria Toxin
Protein Structure, Folding, and Design 2, Proceedings of a DuPont-UCLA Symposium, Steamboat Springs, Colorado, April 1987, ed. D. L. Oxender, vol. 69, 187--202, Alan R. Liss, Inc., New York (1987). 1987
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Eisenberg D, Wesson M, Goodsell D, Wilcox W, Gribskov M, Altschuh D, Rees DC
Solvation Energy Contributions to Binding Energies
Protein Structure, Folding, and Design 2, Proceedings of a DuPont-UCLA Symposium, Steamboat Springs, Colorado, April 1987, ed. D. L. Oxender, vol. 69, 203--213, Alan R. Liss, Inc., New York (1987). 1987
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1970
David Eisenberg
A Solid
Science 169, 46-47 (1970). 1970
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Obituary
In memoriam – Rainer Jaenicke
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